Molecular and Cell Biology of Autoantibodies and Autoimmunity Abstracts by E. K. F. Bautz

Cover of: Molecular and Cell Biology of Autoantibodies and Autoimmunity | E. K. F. Bautz

Published by Springer .

Written in English

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Subjects:

  • Immunology,
  • Medical / Nursing,
  • Health/Fitness

Book details

The Physical Object
FormatPaperback
Number of Pages118
ID Numbers
Open LibraryOL10153096M
ISBN 100387514368
ISBN 109780387514369

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Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease. Editor(s): This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology.

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology.

The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an Molecular and Cell Biology of Autoantibodies and Autoimmunity book team of. The 1st International Workshop in the Molecular and Cell Biology of Autoan­ tibodies and Autoimmunity is convened at a time when recombinant DNA tech­ niques have yielded the first set of data providing initial glimpses of epitopes recognized by autoantibodies.

It's aim is to bring together cell. ISBN: OCLC Number: Notes: Abstracts from the 1st International Workshop in the Molecular and Cell Biology of Autoantibodies and Autoimmunity held Julyin Heidelberg, Germany. Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease.

Kenneth Michael Pollard (Editor) ISBN: pages. MayWiley-Blackwell. Description. This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models.

To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases.

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease: Medicine & Health Science Books @ WELCOME, LET THE FUN BEGIN. Get e-Books "B Cell Biology In Autoimmunity" on Pdf, ePub, Tuebl, Mobi and Audiobook for are more than 1 Million Books that have been enjoyed by people from all over the world.

Always update books hourly, if not looking, search in the book search column. Enjoy % FREE. Autoimmunity, the state in which the immune system reacts against the body’s own normal components, producing disease or functional changes. The human immune system performs a surveillance function, identifying and disposing of antigens—materials such as toxins or infectious microbes that it recognizes as foreign.

This surveillance is carried out mostly by the white blood cells called. Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology.

The book contains 20 chapters and begins with a study of the expression of the Ly-1 gene and V gene families in autoantibodies. This is followed by separate chapters on the structural characteristics of human IgM autoantibodies; human IgV gene segments for autoantibodies; and the genetic basis of anti-DNA immune responses.

Dwight H. Kono, Argyrios N. Theofilopoulos, in Kelley and Firestein's Textbook of Rheumatology (Tenth Edition), Definition and Classification of Pathogenic Autoimmunity.

Autoimmunity —that is, the immune response against self—evokes the specter of “horror autotoxicus,” a term coined by Paul Ehrlich at the turn of the 20th century to depict the perceived disastrous consequences of.

Autoantibodies and Autoimmunity | This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease Kenneth Michael Pollard (Editor) This is Molecular and Cell Biology of Autoantibodies and Autoimmunity book first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and.

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology.

Get this from a library. Autoantibodies and autoimmunity: molecular mechanisms in health and disease. [K Michael Pollard;] -- This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of.

New drugs are often discovered by studying the effects of small molecules. Scientists have now identified two combinations of these chemicals that can disrupt a cellular pathway that is related to the development of autoimmune disease.

Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production.

All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes.

with autoantigens. Autoimmunity induces auto-immune diseases. Recent studies have revealed that such autoantibodies or autoreactive T cells exist even in healthy individuals. The immune system has various mechanisms to suppress the immune response to the self, and the distur-bance of these mechanisms results in auto-immune diseases.

The book contains 20 chapters and begins with a study of the expression of the Ly-1 gene and V gene families in autoantibodies. This is followed by separate chapters on the structural characteristics of human IgM autoantibodies; human IgV gene segments for autoantibodies; and the genetic basis of anti-DNA immune Edition: 1.

Autoimmunity is mediated by a variety of mechanisms, molecular and cellular events, and responses. Predisposition to a given autoimmune response requires the requisite allele(s) that controls. In the immune system, many tolerance checkpoints exist to prevent self-antigens from stimulating the relentless growth of self-reactive B and T lymphocytes.

The genes and molecular pathways underpinning these checkpoints overlap with those involved in tumor suppression. As with an inherited predisposition to cancer, inherited defects in self-tolerance genes typically precipitate autoimmune Cited by:   Autoantibodies as diagnostic biomarkers and reagents in cell biology.

The use of immunofluorescence techniques, in which tissue culture cells were used as antigen substrate for detecting autoantibodies, led to the detection of autoantibodies in various autoimmune diseases, including SLE, scleroderma, dermatomyositis, and mixed connective tissue by: The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecular and genetic basis of these disorders.

Dozens of international experts devote themselves to illuminating the reader in this volume, with discussions on the basic aspects of autoimmune processes. Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues. Any disease that results from such an aberrant immune response is termed an "autoimmune disease".Prominent examples include celiac disease, post-infectious IBS, diabetes mellitus type 1, Henloch Scholein Pupura (HSP) sarcoidosis, systemic lupus erythematosus (SLE), Sjögren syndrome Specialty: Immunology.

This volume covers methods for determination of autoantibodies in rheumatic connective tissue diseases and organ-specific diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on.

Molecular analysis of the autoantibody response in peptide-induced autoimmunity. Putterman C(1), Deocharan B, Diamond B. Author information: (1)Division of Rheumatology, Department of Medicine, and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NYUSA.

[email protected] by: Abstract. One feature of many autoimmune diseases is a humoral autoimmune response against multiple antigens of a given tissue. Although the pathogenic significance of autoantibodies in type I diabetes is unclear, they serve both as essential markers that an autoimmune response has been initiated and as probes to identify their target autoantigens (1–5).Cited by: autoimmunity, and these patients have a higher incidence of thyroid autoimmune disease than the normal population.

Similarly, patients with thyroid autoimmunity have a high incidence of stomach autoantibodies and, to a lesser extent, the clinical disease itself, namely pernicious Size: 1MB. The Journal of Autoimmunity is a parent journal of the Journal of Translational Autoimmunity. treatment of autoimmune diseases.

Special, but not exclusive, attention will be given to papers dealing with genetic, molecular biology, and cellular aspects of the discipline. A cellular and molecular view of T helper 17 cell plasticity in. E-BOOK EXCERPT. Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production.

All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. As the molecular biology behind autoimmune diseases is obscure, an insight on immune pathways, impaired immunity and evolution of autoimmune diseases can.

This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune : Paperback.

Option (b) Molecular development of the autoimmunity takes place with time and its potential causes may be molecular mimicry. It refers to the situation in which one molecule is as same as the other in shape that it binds the similar immune receptors. Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production.

All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes.5/5(1). The serological presence of autoantibodies is diagnostic of autoimmunity, and these autoantibodies may be present for many years before the presentation of autoimmune disease (AID).

Although a pathogenic role has been demonstrated for various autoantibodies reactive with cell surface and extracellular autoantigens, studies using monoclonal. could predispose to increased B-cell responsiveness [].

Finally, studies in genetically manipulated mice have indicated that a variety of interventions that serve to increase B-cell res ponsive ness can lead to the production of autoantibodies and, in the appropriate genetic strain, a lupus-like syndrome [1].

Recently, it has also been shownCited by: The serological presence of autoantibodies is diagnostic of autoimmunity, and these autoantibodies may be present for many years before the presentation of autoimmune disease (AID).

Although a pathogenic role has been demonstrated for various autoantibodies reactive with cell surface and extracellular autoantigens, studies using monoclonal antibodies (mAb) show not all antibodies in the Cited by: 6.

Few therapeutic and diagnostic tools specifically aim at T cells in autoimmune disorders, but are T cells a narrow target in these diseases. Lessons may be learned from celiac disease (CeD), one of the few autoimmune disorders where the T cell driving antigens are known, i.e.

dietary gluten proteins. T cell clonotypes specific to gluten are expanded, persist for decades and express a distinct Cited by: 3.

Our Phase III Molecular Mechanisms and Genetics of Autoimmunity COBRE focuses on understanding the molecular and genetic basis of autoimmune diseases. Since its initial establishment inour COBRE has worked diligently to established partnerships with other OMRF COBRE Cores and OMRF in order to provide the technology and expertise necessary to transform OMRF into an internationally.

"This series is a classic " - Molecular Medicine Today/Trends in Molecular Medicine The second edition of this highly acclaimed, sixteen-volume Encyclopedia now contains new articles and extended coverage of cell biology.

It is thus the most comprehensive and most detailed treatment of molecular biology, cell biology and molecular medicine available today -- designed in collaboration.munity initiated by activation of antigen-specific SELF REACTIVE T cells REACTIVE cytotoxic T cells directly target and destroy normal cells -reactive helper T cells ACTIVATE B cells to make autoantibodies, which directly lead to tissue damage Autoimmune responses always involve activated T cells in some regard.BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc.

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